Tumor Protein P63 (TP63) Peptid
TP63
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
Produktnummer ABIN985398
Kurzübersicht für Tumor Protein P63 (TP63) Peptid (ABIN985398)
Target
p63 (TP63)
(Tumor Protein P63 (TP63))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-TP63 antibody (Catalog #: ARP38379_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Aufreinigung
- Purified
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Tumor Protein P63 (TP63) peptide (Ovalbumin)
TP63 Reaktivität: Human Wirt: Synthetic WB, Imm, SDS
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Konzentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handhabung
- Avoid repeated freeze-thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- p63 (TP63) (Tumor Protein P63 (TP63))
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Hintergrund
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TP63 is a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in the gene encoding TP63 are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8.This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Alias Symbols: B(p51A), B(p51B), EEC3, KET, LMS, OFC8, RHS, SHFM4, TP73L, p51, p63, p73H, p73L, AIS, NBP, p40, TP53L, p53CP, TP53CP
Protein Interaction Partner: FAS,DAXX,EP300,GRB2,HIPK2,HNRNPAB,PPP1R13B,PPP2R5A,TP53,TP63,TP73,WT1,BTRC,GNB2L1,HIPK2,HNRNPAB,SFRS15,UBC,YAP1
Protein Size: 586 -
Molekulargewicht
- 65 kDa
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Gen-ID
- 8626
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NCBI Accession
- NM_001114980, NP_001108452
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UniProt
- Q9H3D4
Target
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